Detection of gene copy number changes in CGH microarrays using a spatially correlated mixture model
نویسندگان
چکیده
منابع مشابه
Detection of gene copy number changes in CGH microarrays using a spatially correlated mixture model
MOTIVATION Comparative genomic hybridization array experiments that investigate gene copy number changes present new challenges for statistical analysis and call for methods that incorporate spatial dependence between sequences along the chromosome. For this purpose, we propose a novel method called CGHmix. It is based on a spatially structured mixture model with three states corresponding to g...
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Comparative genomic hybridization (CGH) microarrays have been used to determine copy number variations (CNVs) and their effects on complex diseases. Detection of absolute CNVs independent of genomic variants of an arbitrary reference sample has been a critical issue in CGH array experiments. Whole genome analysis using massively parallel sequencing with multiple ultra-high resolution CGH arrays...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2006
ISSN: 1460-2059,1367-4803
DOI: 10.1093/bioinformatics/btl035